Basic Information

Symbol
BAX
RNA class
mRNA
Alias
BCL2 Associated X, Apoptosis Regulator BCL2L4 BCL2 Associated X Protein Apoptosis Regulator BAX Bcl-2-Like Protein 4 Bcl2-L-4 BCL2-Associated X Protein Omega BCL2-Associated X Protein Baxdelta2(G8)-RFS Protein Baxdelta2G9omega Baxdelta2omega Baxdelta2G9
Location (GRCh38)
19:48954815-48961798
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138761.4
Sequence length
795.0 nt
GC content
0.6075

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-332.40 kcal/mol
Thermodynamic ensemble
Free energy: -349.15 kcal/mol
Frequency: 0.0000
Diversity: 150.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.((((.(((((((.(((.......))).).)))))).))))..))((((((((((....(((((.(((.(.(((((.((((((((((((((......(((((.....))).))......)))))).)))))))).))))).).))).)))))...))(((((..(((((((((((((.(((((.(..(((((((..((((((((((((....(((((.((.....(((((((....).))).))).....)))))))..)))..(((.((((((.((((((...(((.((..(((.(((.((............)))).).)))..)).))).....))))))..))))))..)))..(((((........(((((.((....)))))))........))))).......((((((.((......)).)))))))))))))))...((.((((..(((...))).)))).)).((((.....))))(((.(((((....)))))..)))....)))))))).)))))...)))))))))))))........))))).....(((..((((.((.......)).))))...))))))))))).(((((.((((((......))))))(((.(.((((((((.(.(((...(((.....(((((((((((...))))).........)))))))))))).)))))))).).).)))...((((((((((((.(((...))).)))).)))))))))))))(((((((((((((.....))).))))))))))...
Thermodynamic Ensemble Prediction
((.((((.(((((((.(((.....,.))).).)))))).))))..))((((((({,{..{.(((((.(((,(.(((((.((((((((((((((.....{(((((.....))).)},}....))))))))))))))).))))).).))).)))))...},((((({,(((((((((((((.(((((.(..(((((((..((((((((((((....(((((.((.....(((((((....).))),,))...,.)))))))..))),.(((.((((((.((((((...(((.((..(((.(((.((,.......,,,.}.)).).)))..)}.))).....))))))..))))))..))).,(((({........(((({{({....}))))))........})))).......((((((.((......)).)))))))))))))))...,{.{(((..(({...,)),)}}}.}},((((..,{{}}}}|||,{{{{|....)))))..))),...)))))))),)))))...))))))))))))).,,.....)))))....,(((..((((.((.,.....)).))))...))))))))))).(((((.((((((......))))))(((.(.((((((((.(.(((...,{.......,{(((((,,{,,..,,,,...,,,...,)))))))}))),,))))))).).).)))...((((((((((((.({,...,)).)))).)))))))))))))(((((((((((((.....)))}))))))))))...

Transcripts

ID Sequence Length GC content
NM_001291428.2 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 844 nt 0.6102
NM_001291429.2 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1360 nt 0.6007
NM_001291430.2 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1213 nt 0.5977
NM_001291431.2 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 596 nt 0.6040
NM_004324.4 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1412 nt 0.6006
NM_138761.4 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 795 nt 0.6075
NM_138763.4 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 648 nt 0.6034
NM_138764.5 NCBI
GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 756 nt 0.6045
Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019] CIViC Summary for BAX Gene

Forensic Context

A study in mice demonstrated that the protein expression of the BAX in postmortem skin peaked at 8–12 hours after death and then gradually decreased, while its mRNA expression showed a prominent change at 4 hours [Xie et al. DOI:10.1007/S12024-023-00757-5]. These statistically significant, time-dependent changes in the BAX's protein and mRNA levels indicate its potential application for estimating the early postmortem interval. A study in human cell cultures demonstrated that serum from polytraumatised patients significantly decreased apoptosis of human bone-marrow stromal cells compared to control serum, an effect associated with an inhibition of the BAX mRNA expression [Eid et al. DOI:10.1302/0301-620X.88B10.17139].