Basic Information

Symbol
SORBS2
RNA class
mRNA
Alias
Sorbin And SH3 Domain Containing 2 ARGBP2 KIAA0777 Sorbin And SH3 Domain-Containing Protein 2 Arg/Abl-Interacting Protein 2 Arg-Binding Protein 2 Arg/Abl Interacting Protein Arg Binding Protein 2 PRO0618 ArgBP2 Sorbin
Location (GRCh38)
4:185585444-185956652
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395207.1
Sequence length
6774.0 nt
GC content
0.4711

Transcripts

ID Sequence Length GC content
NM_001145670.2 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 4788 nt 0.4415
NM_001145671.3 NCBI
AGUUGUAAAGCAAACAGUGUAGGUAUUGGAAGCCGUUCACACCUCCUUU… 4639 nt 0.4419
NM_001145672.2 NCBI
AAGCAGAUAGGUUUCAGAGAUAAAGAGUGAAACCAAAAACACCGCACAC… 4277 nt 0.4283
NM_001145673.3 NCBI
AAAUCAUUUGUCUUCAGUCUUAAGAAUAGACUGACAACAGAUACUGCUA… 5105 nt 0.4372
NM_001145674.3 NCBI
AGCAGUAGCAGAGGCAGCUUCUGAGAGCCUGGGCAGGCAGCAGCUGGCU… 5227 nt 0.4632
NM_001145675.3 NCBI
AGCAGUAGCAGAGGCAGCUUCUGAGAGCCUGGGCAGGCAGCAGCUGGCU… 3691 nt 0.4243
NM_001270771.3 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 6141 nt 0.4631
NM_001394245.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6668 nt 0.4723
NM_001394246.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6611 nt 0.4728
NM_001394247.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6607 nt 0.4728
Showing 1 to 10 of 42 entries
Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.