Basic Information

Symbol
SORBS2
RNA class
mRNA
Alias
Sorbin And SH3 Domain Containing 2 ARGBP2 KIAA0777 Sorbin And SH3 Domain-Containing Protein 2 Arg/Abl-Interacting Protein 2 Arg-Binding Protein 2 Arg/Abl Interacting Protein Arg Binding Protein 2 PRO0618 ArgBP2 Sorbin
Location (GRCh38)
4:185585444-185956652
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395207.1
Sequence length
6774.0 nt
GC content
0.4711

Transcripts

ID Sequence Length GC content
NM_001394248.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 6188 nt 0.4696
NM_001394249.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6542 nt 0.4731
NM_001394250.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6527 nt 0.4737
NM_001394251.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6418 nt 0.4674
NM_001394252.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6414 nt 0.4674
NM_001394253.1 NCBI
AUUCCUGCACAAGCCACACACAGCAGACUUGUAUUUCUGUCAAGGGCUC… 5964 nt 0.4631
NM_001394254.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6506 nt 0.4719
NM_001394255.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 6010 nt 0.4646
NM_001394256.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6368 nt 0.4684
NM_001394257.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 6014 nt 0.4646
Showing 11 to 20 of 42 entries
Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.