Basic Information

Symbol
SORBS2
RNA class
mRNA
Alias
Sorbin And SH3 Domain Containing 2 ARGBP2 KIAA0777 Sorbin And SH3 Domain-Containing Protein 2 Arg/Abl-Interacting Protein 2 Arg-Binding Protein 2 Arg/Abl Interacting Protein Arg Binding Protein 2 PRO0618 ArgBP2 Sorbin
Location (GRCh38)
4:185585444-185956652
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395207.1
Sequence length
6774.0 nt
GC content
0.4711

Transcripts

ID Sequence Length GC content
NM_001394258.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6518 nt 0.4722
NM_001394259.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6323 nt 0.4694
NM_001394260.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6369 nt 0.4685
NM_001394261.1 NCBI
AUUCCUGCACAAGCCACACACAGCAGACUUGUAUUUCUGUCAAGGGCUC… 5871 nt 0.4623
NM_001394262.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 5945 nt 0.4648
NM_001394263.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6299 nt 0.4686
NM_001394264.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 6035 nt 0.4706
NM_001394265.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6211 nt 0.4679
NM_001394266.1 NCBI
AUUAGGAGUCACAGUGAUGUGGAAUCAACUUUGUCUUUCUGAAAAGCUG… 5868 nt 0.4594
NM_001394267.1 NCBI
AGUCUCCUUUUAUUGUGGAUGAACACCACGUACAUGCCGUAAAUGCUCC… 5852 nt 0.4639
Showing 21 to 30 of 42 entries
Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.