Basic Information

Symbol
SORBS2
RNA class
mRNA
Alias
Sorbin And SH3 Domain Containing 2 ARGBP2 KIAA0777 Sorbin And SH3 Domain-Containing Protein 2 Arg/Abl-Interacting Protein 2 Arg-Binding Protein 2 Arg/Abl Interacting Protein Arg Binding Protein 2 PRO0618 ArgBP2 Sorbin
Location (GRCh38)
4:185585444-185956652
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395207.1
Sequence length
6774.0 nt
GC content
0.4711

Transcripts

ID Sequence Length GC content
NM_001394268.1 NCBI
AUUAGGAGUCACAGUGAUGUGGAAUCAACUUUGUCUUUCUGAAAAGCUG… 5937 nt 0.4593
NM_001394270.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6202 nt 0.4679
NM_001394271.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6275 nt 0.4677
NM_001394272.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6206 nt 0.4679
NM_001394273.1 NCBI
AGCAGUAGCAGAGGCAGCUUCUGAGAGCCUGGGCAGGCAGCAGCUGGCU… 5488 nt 0.4679
NM_001394274.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6230 nt 0.4687
NM_001394275.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6161 nt 0.4689
NM_001394276.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6007 nt 0.4571
NM_001394277.1 NCBI
AGCAGUAGCAGAGGCAGCUUCUGAGAGCCUGGGCAGGCAGCAGCUGGCU… 5272 nt 0.4621
NM_001395207.1 NCBI
AUAUUCUGCUGAGCUUCGCCCUGGAAGAAGCCUCUUUUAUACAUCUCUU… 6774 nt 0.4711
Showing 31 to 40 of 42 entries
Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.