Basic Information

Symbol
SOS1
RNA class
mRNA
Alias
SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 HGF GF1 Gingival Fibromatosis, Hereditary, 1 Son Of Sevenless Homolog 1 GINGF SOS-1 Son Of Sevenless Homolog 1 (Drosophila) Guanine Nucleotide Exchange Factor GGF1 NS4
Location (GRCh38)
2:38962206-39124345
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005633.4
Sequence length
8906.0 nt
GC content
0.4065

Transcripts

ID Sequence Length GC content
NM_001382394.1 NCBI
AUUAGAGAAAAAAGGCGACAGGCAUUCUGAAUAGCAGGAGACAGAGACA… 8395 nt 0.3755
NM_001382395.1 NCBI
AGUAGCGAGCAGGUUCAGUUCGCUAGUAGGAAGCUCCAGCGCUACACCG… 8861 nt 0.4060
NM_005633.4 NCBI
AGUAGCGAGCAGGUUCAGUUCGCUAGUAGGAAGCUCCAGCGCUACACCG… 8906 nt 0.4065
Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008] CIViC Summary for SOS1 Gene

Forensic Context

A study in mice demonstrated that selective breeding for high and low ethanol preference from HS-CC founders significantly altered gene expression and network connectivity in the nucleus accumbens shell [Colville et al. DOI:10.1111/Gbb.12367].