Basic Information

Symbol
SOX1
RNA class
mRNA
Alias
SRY-Box Transcription Factor 1 SRY (Sex Determining Region Y)-Box 1 SRY-Related HMG-Box Gene 1 Transcription Factor SOX-1 SRY-Box 1
Location (GRCh38)
13:112067149-112071706
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005986.3
Sequence length
4558.0 nt
GC content
0.5575

Transcripts

ID Sequence Length GC content
NM_005986.3 NCBI
AGCACAUGCCCAGCGCACGCGGCGCGCCGCCCUGCUAGAAGUUGCAGCC… 4558 nt 0.5575
Summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the SOX1 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption in postmortem prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159].