Basic Information

Symbol
SOX17
RNA class
mRNA
Alias
SRY-Box Transcription Factor 17 SRY (Sex Determining Region Y)-Box 17 Transcription Factor SOX-17 SRY-Box 17 SRY-Related HMG-Box Transcription Factor SOX17 PPH7 VUR3
Location (GRCh38)
8:54457935-54460892
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022454.4
Sequence length
2346.0 nt
GC content
0.5818

Transcripts

ID Sequence Length GC content
NM_022454.4 NCBI
GCAGUGUCACUAGGCCGGCUGGGGGCCCUGGGUACGCUGUAGACCAGAC… 2346 nt 0.5818
Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human patients with severe erectile dysfunction demonstrated that the SOX17 showed abundant expression level in a specific endothelial cell subcluster (ECs III) identified as arteriole endothelial cells within the corpus cavernosum [Fang et al. DOI:10.3389/fendo.2022.874915]. A review of single-cell sequencing in mouse models of myocardial infarction identified the SOX17 as a marker for microvascular and arterial endothelial cells, expressed in specific endothelial cell clusters (EC1 and EC2) following cardiac injury [Bian et al. DOI:10.3892/mmr.2025.13680].