Basic Information

Symbol
SOX5
RNA class
mRNA
Alias
SRY-Box Transcription Factor 5 L-SOX5 SRY (Sex Determining Region Y)-Box 5 Transcription Factor SOX-5 SRY-Box 5 MGC35153 L-SOX5B L-SOX5F LAMSHF
Location (GRCh38)
12:23529504-24562544
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006940.6
Sequence length
7076.0 nt
GC content
0.3919

Transcripts

ID Sequence Length GC content
NM_001261414.3 NCBI
ACACACACCGGCACACACGCACACACACAGACACACACACACAGAGUGA… 7135 nt 0.3940
NM_001261415.3 NCBI
ACUCCCUGACCAGAUGCUGCGGUGCACGGGGCAGCCACCAUCUCUGCAU… 7028 nt 0.3927
NM_001330785.2 NCBI
ACUUGACAGGUUCAGUUGGAGACGAUCAUAGGUGGCUGCUGUGACAAAG… 6971 nt 0.3905
NM_006940.6 NCBI
ACUUGACAGGUUCAGUUGGAGACGAUCAUAGGUGGCUGCUGUGACAAAG… 7076 nt 0.3919
NM_152989.5 NCBI
ACACACACCGGCACACACGCACACACACAGACACACACACACAGAGUGA… 7384 nt 0.3983
NM_178010.4 NCBI
AGACUGUUGGAGAUUUGUGCCAUAGGAGCUGUGCAUGCAUGAUGAAGUG… 5883 nt 0.3675
Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the SOX5 is expressed in oligodendrocyte cell bodies in white matter and myelinated gray matter of the adult central nervous system [Miguel-Hidalgo et al. DOI:10.1016/J.Pnpbp.2017.08.009]. In a separate human ex vivo skin model of burn injury, mRNA levels of the SOX5 showed no differential expression within the first 24 hours post-burn [Foessl et al. DOI:10.3390/ijms22179209].