Basic Information

Symbol
SOX6
RNA class
mRNA
Alias
SRY-Box Transcription Factor 6 SRY (Sex Determining Region Y)-Box 6 Transcription Factor SOX-6 SRY-Box 6 SRY-Box Containing Gene 6 HSSOX6 TOLCAS SOXD
Location (GRCh38)
11:15966449-16739591
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001367873.1
Sequence length
9304.0 nt
GC content
0.4184

Transcripts

ID Sequence Length GC content
NM_001145811.2 NCBI
AUCUCUAUAAAACAUCAGGCUGGGAGGUGGUGUGUGCCUGUAGUCUCAA… 8929 nt 0.4194
NM_001145819.2 NCBI
GUUAGGAGAGACCAUUGGGGAUAGGAAAGAUGAAAGGUCAUGGUGAGCU… 8915 nt 0.4193
NM_001367872.1 NCBI
AGAGGCCCCGCCUUCGGCUGGUGGAGGAAGCGUUCCCGCGGAUGUGUAU… 9037 nt 0.4219
NM_001367873.1 NCBI
AUAACUUACUGUCAACUGUGAGGCAAACCACAAAGCUCCACUGUUGCUC… 9304 nt 0.4184
NM_017508.3 NCBI
GUUAGGAGAGACCAUUGGGGAUAGGAAAGAUGAAAGGUCAUGGUGAGCU… 8975 nt 0.4181
NM_033326.3 NCBI
GUCACUUUCAUGAAUUCAAAGGCAAUUUACCAGUGAUUUCUGGGUGCUG… 8865 nt 0.4187
Summary

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Forensic Context

A study in mice and human cells demonstrated that the SOX6 is an adult-specific transcription factor identified in prior studies of erythroid development [Cai et al. DOI:10.73/pnas.2008672117].