Basic Information

Symbol
SP100
RNA class
mRNA
Alias
SP100 Nuclear Antigen Nuclear Dot-Associated Sp100 Protein Nuclear Autoantigen Sp-100 Speckled 100 KDa SP100-HMG Nuclear Autoantigen Nuclear Antigen Sp100 Lysp100b
Location (GRCh38)
2:230415942-230545606
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001080391.2
Sequence length
5414.0 nt
GC content
0.4213

Transcripts

ID Sequence Length GC content
NM_001080391.2 NCBI
GCUUGGGGCCUGGGCAGCCACACUGCACGCAGGCUGGGCCGACUGAGGG… 5414 nt 0.4213
NM_001206701.2 NCBI
GCUUGGGGCCUGGGCAGCCACACUGCACGCAGGCUGGGCCGACUGAGGG… 2263 nt 0.4432
NM_001206702.2 NCBI
GCUUGGGGCCUGGGCAGCCACACUGCACGCAGGCUGGGCCGACUGAGGG… 1957 nt 0.4384
NM_001206703.2 NCBI
GCUUGGGGCCUGGGCAGCCACACUGCACGCAGGCUGGGCCGACUGAGGG… 1873 nt 0.4378
NM_001206704.2 NCBI
AGACGCUGUGGUCUCACCUGUCCUGGCAAGGGGCCUCUGCCGGCUGUUC… 2037 nt 0.4212
NM_003113.4 NCBI
GCUUGGGGCCUGGGCAGCCACACUGCACGCAGGCUGGGCCGACUGAGGG… 3623 nt 0.4162
Summary

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

Forensic Context

A study in humans demonstrated that exosomes from heat stroke patients showed significant upregulation of the SP100 mRNA, which is associated with inflammatory response, as verified by qPCR array [Li et al. DOI:10.3389/fimmu.2021.624753].