Basic Information

Symbol
SP110
RNA class
mRNA
Alias
SP110 Nuclear Body Protein Interferon-Induced Protein 41, 30kD Transcriptional Coactivator Sp110 Interferon-Induced Protein 41/75 Speckled 110 KDa IFI41 IFI75 Interferon-Induced Protein 75, 52kD Sp110 Nuclear Body Protein Phosphoprotein 41 Phosphoprotein 75 IPR1 VODI
Location (GRCh38)
2:230165186-230225729
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_080424.4
Sequence length
6192.0 nt
GC content
0.4236

Transcripts

ID Sequence Length GC content
NM_001185015.2 NCBI
AGAGCCAGCCCCACGAGGCCACGGAAGACAGGGUCACUUGUUCCUGCCA… 2023 nt 0.4706
NM_001378442.1 NCBI
AGAGCCAGCCCCACGAGGCCACGGAAGACAGGGUCACUUGUUCCUGCCA… 6341 nt 0.4286
NM_001378443.1 NCBI
ACAGACUUCCUGUUUUGCCUGCUAGCAUCUCCCUGUAACUCUCCCAAUC… 6270 nt 0.4278
NM_001378444.1 NCBI
AGAGCCAGCCCCACGAGGCCACGGAAGACAGGGUCACUUGUUCCUGCCA… 6263 nt 0.4246
NM_001378445.1 NCBI
AGAGCCAGCCCCACGAGGCCACGGAAGACAGGGUCACUUGUUCCUGCCA… 6191 nt 0.4245
NM_001378446.1 NCBI
AGAGCCAGCCCCACGAGGCCACGGAAGACAGGGUCACUUGUUCCUGCCA… 6050 nt 0.4236
NM_001378447.1 NCBI
ACAGACUUCCUGUUUUGCCUGCUAGCAUCUCCCUGUAACUCUCCCAAUC… 1802 nt 0.4678
NM_004509.5 NCBI
ACAGACUUCCUGUUUUGCCUGCUAGCAUCUCCCUGUAACUCUCCCAAUC… 6120 nt 0.4235
NM_004510.4 NCBI
ACAGACUUCCUGUUUUGCCUGCUAGCAUCUCCCUGUAACUCUCCCAAUC… 1952 nt 0.4693
NM_080424.4 NCBI
ACAGACUUCCUGUUUUGCCUGCUAGCAUCUCCCUGUAACUCUCCCAAUC… 6192 nt 0.4236
Summary

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the SP110 transcript, a pro-apoptotic regulator, increased in abundance within 0.5 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].