Basic Information

Symbol
SPARCL1
RNA class
mRNA
Alias
SPARC Like 1 MAST9 High Endothelial Venule Protein SPARC-Like Protein 1 MAST 9 Hevin Proliferation-Inducing Protein 33 SPARC-Like 1 (Mast9, Hevin) SPARC-Like 1 (Hevin) PIG33 SC1
Location (GRCh38)
4:87473329-87531118
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004684.6
Sequence length
2778.0 nt
GC content
0.4208

Transcripts

ID Sequence Length GC content
NM_001128310.3 NCBI
AAGCACUGCCUGUAAAGCCCUCGCAUGAGAGGCCAGCCUGCUAGGGAAA… 2880 nt 0.4177
NM_001291976.2 NCBI
AAGCACUGCCUGUAAAGCCCUCGCAUGAGAGGCCAGCCUGCUAGGGAAA… 2887 nt 0.4226
NM_001291977.2 NCBI
AAGCACUGCCUGUAAAGCCCUCGCAUGAGAGGCCAGCCUGCUAGGGAAA… 2538 nt 0.4208
NM_004684.6 NCBI
AAGCACUGCCUGUAAAGCCCUCGCAUGAGAGGCCAGCCUGCUAGGGAAA… 2778 nt 0.4208
Summary

Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in regulation of synapse organization. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human cardiac tissue from ischemic cardiomyopathy patients identified the SPARCL1 as a gene with important roles in disease and classified it as a potential druggable target for heart disease [Simonson et al. DOI:10.1016/j.celrep.2023.112086].