Basic Information

Symbol
SPDEF
RNA class
mRNA
Alias
SAM Pointed Domain Containing ETS Transcription Factor PDEF BA375E1.3 SAM Pointed Domain-Containing Ets Transcription Factor Prostate Epithelium-Specific Ets Transcription Factor Prostate-Derived Ets Factor Prostate-Specific Ets PSE
Location (GRCh38)
6:34537796-34556333
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012391.3
Sequence length
1910.0 nt
GC content
0.6461

Transcripts

ID Sequence Length GC content
NM_001252294.2 NCBI
CUUCAUCUCGCGGCUGUCUGACUUCCUCCCAGCACAUUCCUGCACUCUG… 1862 nt 0.6477
NM_012391.3 NCBI
CUUCAUCUCGCGGCUGUCUGACUUCCUCCCAGCACAUUCCUGCACUCUG… 1910 nt 0.6461
Summary

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

No relevant information is available at the moment.