Basic Information

Symbol
SPHK1
RNA class
mRNA
Alias
Sphingosine Kinase 1 SPHK Acetyltransferase SPHK1 SPK 1 SK 1 EC 2.7.1.91 EC 2.3.1.- SK1 SPK
Location (GRCh38)
17:76376584-76387860
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001142601.2
Sequence length
1816.0 nt
GC content
0.6498

Transcripts

ID Sequence Length GC content
NM_001142601.2 NCBI
AGUGCCCUCCCCGCUCCGCGGCGCCGGCUGCGAAGUUGAGCGAAAAGUU… 1816 nt 0.6498
NM_001142602.2 NCBI
GGGAUUGUAGGCUUAGUCACACGGCGGGGGCGCCCUCGGAGGCACCGGA… 1791 nt 0.6477
NM_001355139.2 NCBI
ACCUUCCCGGAACGCGCUCGGGACGCUCUGGACCCAGCGGGGACUGCCC… 1944 nt 0.6548
NM_021972.4 NCBI
AGUGCCCUCCCCGCUCCGCGGCGCCGGCUGCGAAGUUGAGCGAAAAGUU… 1858 nt 0.6469
NM_182965.3 NCBI
AGUGCCCUCCCCGCUCCGCGGCGCCGGCUGCGAAGUUGAGCGAAAAGUU… 2179 nt 0.6627
Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017] CIViC Summary for SPHK1 Gene

Forensic Context

A single-cell transcriptomic analysis in a rat model of radiation-induced lung injury identified the SPHK1 as an orthologous rat gene associated with inflammatory processes [Shi et al. DOI:10.17305/bb.2024.10357].