Basic Information

Symbol
SPHKAP
RNA class
mRNA
Alias
SPHK1 Interactor, AKAP Domain Containing SKIP Sphingosine Kinase Type 1-Interacting Protein SPHK1-Interactor And AKAP Domain-Containing Protein A-Kinase Anchor Protein SPHKAP SPHK1 (Sphingosine Kinase Type 1) Interacting Protein KIAA1678
Location (GRCh38)
2:227979955-228181687
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001142644.2
Sequence length
6954.0 nt
GC content
0.4557

Transcripts

ID Sequence Length GC content
NM_001142644.2 NCBI
AGUCUGGCACUCUGGGAGCUGGGUCCUAGCACCACAGACUUAUCCUUCG… 6954 nt 0.4557
NM_030623.4 NCBI
AGUCUGGCACUCUGGGAGCUGGGUCCUAGCACCACAGACUUAUCCUUCG… 6867 nt 0.4559
Summary

Enables protein kinase A binding activity. Predicted to be located in Z disc. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice and rats demonstrated that the SPHKAP was identified as a downregulated same-trend differentially expressed gene in the corpus cavernosum of animals with age-related erectile dysfunction, where multi-omics analyses revealed conserved molecular mechanisms involving downregulated mitochondrial activity and extracellular matrix alterations [Long et al. DOI:10.1093/sexmed/qfaf078].