Basic Information

Symbol
SPI1
RNA class
mRNA
Alias
Spi-1 Proto-Oncogene SPI-A SFPI1 SPI-1 PU.1 OF Hematopoietic Transcription Factor PU.1 31 KDa Transforming Protein Transcription Factor PU.1 Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene 31 KDa-Transforming Protein AGM10
Location (GRCh38)
11:47354860-47409369
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003120.3
Sequence length
1374.0 nt
GC content
0.6521

Transcripts

ID Sequence Length GC content
NM_001080547.2 NCBI
AAAAUCAGGAACUUGUGCUGGCCCUGCAAUGUCAAGGGAGGGGGCUCAC… 1377 nt 0.6521
NM_003120.3 NCBI
AAAAUCAGGAACUUGUGCUGGCCCUGCAAUGUCAAGGGAGGGGGCUCAC… 1374 nt 0.6521
Summary

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the SPI1 as a core transcription factor highly expressed in the peripheral blood of sepsis patients, where its expression was positively correlated with 28-day survival rates and it was primarily localized to monocyte cell lines [Liu et al. DOI:10.0000000000002072]. In porcine skin exposed to bromine vapor, the SPI1 was significantly upregulated in the 20-minute exposure group and was associated with altered chemokine signaling pathways [Rogers et al. DOI:10.1002/jbt.20383].