Basic Information

Symbol
SPINK1
RNA class
mRNA
Alias
Serine Peptidase Inhibitor Kazal Type 1 PSTI TATI Spink3 PCTT Serine Protease Inhibitor, Kazal Type 1 Serine Protease Inhibitor Kazal-Type 1 Pancreatic Secretory Trypsin Inhibitor Tumor-Associated Trypsin Inhibitor TCP
Location (GRCh38)
5:147824572-147831671
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001379610.1
Sequence length
413.0 nt
GC content
0.4625

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-114.80 kcal/mol
Thermodynamic ensemble
Free energy: -122.87 kcal/mol
Frequency: 0.0000
Diversity: 94.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((....(.((((.((((...))))...)))).)..)))))).(((((((.(((((...))))))))((((....)))).(((((....)))))(((((((((..((((((((((((.((....))......(((((..((((((...))))))...))))).)))))))))))))))...))))))................))))..(((((((((((...))).(((((((((((((.(((((.(((........))).)))))..(((((........))))).(((((....................)))))((((((........)))))).........)))))).))).))))((((((.....))))))............))))))))........
Thermodynamic Ensemble Prediction
...((((((..,.{.((((.((((...))))...)))).}.,)))))).(({((((.(((({...})))))))((((....)))).(((((....)))))(((((((((..((((((((((((.(..{{{{{{{,{{{({{{{..,|||||,,}),,)),}}})),,).)))))))))))))))...))))))......,.....||..}}}),.((((((({{((...))),(((((((((((((.{((((.{{{......}.}}}.))))).,(((((,.....,,)))))}{{{{{............,{{,,{|,|||||{{((({..,,,..,))))))}},},....))))))}})).))))|(((((.....)))))|,,,....}},,.})))))))........

Transcripts

ID Sequence Length GC content
NM_001354966.2 NCBI
AAUACUUCUCCUUGCUGCUGCCAUGUGAAGAAGGAUGUGUUUGCUUCUC… 606 nt 0.4769
NM_001379610.1 NCBI
AUCUGCCAUAUGACCCUUCCAGUCCCAGGCUUCUGAAGAGACGUGGUAA… 413 nt 0.4625
NM_003122.5 NCBI
AAUACUUCUCCUUGCUGCUGCCAUGUGAAGAAGGAUGUGUUUGCUUCUC… 573 nt 0.4729
Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

Forensic Context

A study in rats demonstrated that the SPINK1 was significantly altered in expression on day 1 after a 20% total body surface area burn injury, where it was classified as a metabolism gene [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025]. In nonhuman primates, transcriptomic analysis of radiation-induced lung injury identified the SPINK1 as the top upregulated transcript in survivor-specific differentially expressed genes, with its processes related to cell-cycle regulation and repair [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].