Basic Information

Symbol
SPINK7
RNA class
mRNA
Alias
Serine Peptidase Inhibitor Kazal Type 7 ECG2 ECRG2 Esophagus Cancer-Related Gene 2 Protein Serine Protease Inhibitor Kazal-Type 7 ECRG-2 Serine Peptidase Inhibitor, Kazal Type 7 (Putative) Serine Peptidase Inhibitor Kazal Type 7 (Putative) Esophagus Cancer Related Gene 2 Esophagus Cancer-Related Gene-2
Location (GRCh38)
5:148312419-148315922
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032566.3
Sequence length
554.0 nt
GC content
0.4404

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-149.50 kcal/mol
Thermodynamic ensemble
Free energy: -160.92 kcal/mol
Frequency: 0.0000
Diversity: 174.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.....((((((..(((.....)))..))))))..(((((.(((..((((((((...(((((((((((((((((........)))))...)))))))))..(((((........)))))(((((.((((((.((........)))))))))))))...........((((...((((.(((........)))))))...)))).........((((((....)))))))))....))))))))..))).....)))))...((((((((....((.(((((.(((((.(((..((((......))))..))).))))))))))..))...((((..((((.(((((......)))))..))))..)).)).))))))))(((((((.....)))))))(((.(((.((..(((((((((((((((((((..(((((...........)))))))).......))))))....)))))....))))).)).))).)))..)))))..(((.((((((((.........)))))))).)))..........
Thermodynamic Ensemble Prediction
.((((,...{.((((((..(((.....)))..)))))).,..,||,|,,,,..,,,,..}}.||..|||||(((((((,......{((,{((((.{{{{{|,,|..,,{(({((,{{{,||||||{(((,{(((((,((........}}))))}}))))}...,,{.,|,.}}|,,.,{{{{{(((,.,{{{{{|||||||{{{{{,{{,{...|,.{{||||...,}))))},.}|...}))).)))..,}},|...,,}},...((((((((....,,.((((,,(((((.(((..((((......))))..))).)))))))))),,|,...({(({,,,{(,(((({......))))),.))))..}}.}},))))))))(((((((.....)))))))....||}}},..,||||||||||,,|{||||.{{((((,,....},,..))))))}}.....,,})))),}}}.}},))},,..,,,}.)}.}))}}))}})),))}.{{{,(((({((,.........,)))))))..,,)}}})))...

Transcripts

ID Sequence Length GC content
NM_032566.3 NCBI
AUGGUCGAUGCAGCUGUAGUGACAAUCUCAGAGCAGCUUCUACACCACA… 554 nt 0.4404
Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the SPINK7 mRNA is abundantly expressed in both saliva and vaginal secretion, with greater read fractions in saliva, and exhibits cross-reactivity with menstrual blood [Yu et al. DOI:10.1016/j.fsigen.2025.103416].