Basic Information

Symbol
SPINT1
RNA class
mRNA
Alias
Serine Peptidase Inhibitor, Kunitz Type 1 HAI-1 MANSC2 HAI Hepatocyte Growth Factor Activator Inhibitor Type 1 Serine Protease Inhibitor, Kunitz Type 1 Kunitz-Type Protease Inhibitor 1 HAI1
Location (GRCh38)
15:40843513-40858383
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003710.4
Sequence length
2978.0 nt
GC content
0.6017

Transcripts

ID Sequence Length GC content
NM_001032367.2 NCBI
CCCUUCUUCUCAGGUCACCAGCACCCUCGGAACCCAGAGGCCCGCGCUC… 2852 nt 0.5961
NM_001386873.1 NCBI
AGUUUCACCAGAAACCAGGGGGAGAAGGCGGCCGAGCCCCAGCUCUCCG… 3118 nt 0.6068
NM_001386874.1 NCBI
AGUUUCACCAGAAACCAGGGGGAGAAGGCGGCCGAGCCCCAGCUCUCCG… 2900 nt 0.6024
NM_001386875.1 NCBI
AGUUUCACCAGAAACCAGGGGGAGAAGGCGGCCGAGCCCCAGCUCUCCG… 2852 nt 0.6013
NM_003710.4 NCBI
AGUUUCACCAGAAACCAGGGGGAGAAGGCGGCCGAGCCCCAGCUCUCCG… 2978 nt 0.6017
NM_181642.3 NCBI
AGUUUCACCAGAAACCAGGGGGAGAAGGCGGCCGAGCCCCAGCUCUCCG… 3026 nt 0.6028
Summary

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the SPINT1 as a protein target of hepatocyte nuclear factor 4 alpha (HNF4A) that was up-regulated in both liver and plasma of patients with alcohol-associated hepatitis [Argemi et al. DOI:10.1016/J.Ajpath.2022.08.009].