Basic Information

Symbol
SPNS2
RNA class
mRNA
Alias
SPNS Lysolipid Transporter 2, Sphingosine-1-Phosphate SLC63A2 Sphingosine-1-Phosphate Transporter SPNS2 Solute Carrier Family 63 Member 2 Sphingolipid Transporter 2 Protein Spinster Homolog 2 Spinster Homolog 2 (Drosophila) SPNS Sphingolipid Transporter 2 Spinster Homolog 2 DFNB115 SLC62A2
Location (GRCh38)
17:4498850-4539036
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001124758.3
Sequence length
3404.0 nt
GC content
0.6416

Transcripts

ID Sequence Length GC content
NM_001124758.3 NCBI
GCAGCGAGCUGAGCGGUGGCAGCGCCGCAGCCGGGGCCGGAGCGCAGGA… 3404 nt 0.6416
Summary

The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]

Forensic Context

A study in human postmortem dorsolateral prefrontal cortex demonstrated that the SPNS2 exhibited higher expression in individuals with major depressive disorder compared to non-psychiatric controls [Pantazatos et al. DOI:10.1038/mp.2016.130].