Basic Information

Symbol
SPOCK2
RNA class
mRNA
Alias
SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2 Testican-2 KIAA0275 Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2 TICN2
Location (GRCh38)
10:72059034-72089032
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001244950.2
Sequence length
5224.0 nt
GC content
0.5850

Transcripts

ID Sequence Length GC content
NM_001134434.1 NCBI
AGUUGUUAUACGGCUUUUGUCUUAACGAAGCCACCCAUUACGGUAUGAU… 1284 nt 0.5818
NM_001244950.2 NCBI
GAUUCUCUCUCCCUCUCCGCGUCCAGUGCUGGGCUUUUUCAGACAAGUG… 5224 nt 0.5850
NM_014767.2 NCBI
AGUUGUUAUACGGCUUUUGUCUUAACGAAGCCACCCAUUACGGUAUGAU… 5345 nt 0.5813
Summary

This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in humans identified the SPOCK2 as a diagnostic marker for sepsis, where it was part of a five-gene model constructed via machine learning that achieved an AUC of 0.987 on a validation set [Wang et al. DOI:10.3390/ijms26093993].