Basic Information

Symbol
SPOCK3
RNA class
mRNA
Alias
SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 3 Testican-3 Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3 SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 3 TICN3 SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 3 HSAJ1454 TES-3
Location (GRCh38)
4:166733384-167234796
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001040159.2
Sequence length
2884.0 nt
GC content
0.3665

Transcripts

ID Sequence Length GC content
NM_001040159.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2884 nt 0.3665
NM_001204352.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2965 nt 0.3676
NM_001204353.1 NCBI
GUGCCCGCUCGGGCUGCUGCGGCUGGGGCUUGCUUCCUUAUACCCACCU… 2797 nt 0.3679
NM_001204354.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2838 nt 0.3647
NM_001204355.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2723 nt 0.3617
NM_001204356.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2764 nt 0.3614
NM_001204358.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 1398 nt 0.4192
NM_001251967.2 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2599 nt 0.3548
NM_016950.3 NCBI
GCAUUUCCAGCAGGAGCUGCGAGCACAGUGCUGGCUCACAACAAGAUGC… 2893 nt 0.3667
Summary

This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in humans demonstrated that the SPOCK3 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].