Basic Information

Symbol
SPON1
RNA class
mRNA
Alias
Spondin 1 F-Spondin KIAA0762 Spondin 1, (F-Spondin) Extracellular Matrix Protein Vascular Smooth Muscle Cell Growth-Promoting Factor Spondin-1 Spondin 1, Extracellular Matrix Protein VSGP/F-Spondin VSGP
Location (GRCh38)
11:13962694-14268133
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006108.4
Sequence length
5052.0 nt
GC content
0.4850

Transcripts

ID Sequence Length GC content
NM_006108.4 NCBI
AGCUCAGCGCAGCUCCGCGGCCGCCAAGCCGAGGCGGGCACGGUCUCCG… 5052 nt 0.4850
Summary

Predicted to enable LBD domain binding activity and metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans demonstrated that the SPON1 was downregulated during continuous weight loss from 5 to 12 months in weight losers [Bollepalli et al. DOI:10.1038/ijo.2017.245].