Basic Information

Symbol
SPON2
RNA class
mRNA
Alias
Spondin 2 DIL1 Mindin Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 1 Spondin 2, Extracellular Matrix Protein M-Spondin Spondin-2 DIL-1
Location (GRCh38)
4:1166932-1208962
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012445.4
Sequence length
1579.0 nt
GC content
0.6536

Transcripts

ID Sequence Length GC content
NM_001128325.3 NCBI
AGCCACUUCCAGCAUGUAGACUGAAGUCAGGCCACGCACAGGGCUCUCC… 1776 nt 0.6503
NM_001199021.2 NCBI
GUGUUUGUGAACUGGCGAUGUGAUCGAGGGCACGGGUGCUGGGCUUCCC… 2043 nt 0.6417
NM_012445.4 NCBI
ACCCGACCGCUGCCGGCCGCGCUCCCGCUGCUCCUGCCGGGUGAUGGAA… 1579 nt 0.6536
Summary

Predicted to enable antigen binding activity; lipopolysaccharide binding activity; and metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including defense response to other organism; opsonization; and positive regulation of cytokine production. Located in extracellular exosome. Biomarker of meningioma. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in human menstrual blood-derived stem cells (MenSCs) identified the SPON2 as a differentially-expressed gene that was down-regulated with increasing passage number [Chen et al. DOI:PMC4713568]. Separately, a multi-omics study in human sepsis patients identified the SPON2 as a potential biomarker significantly associated with 28-day mortality via Mendelian randomization analysis from a low-risk, downregulated gene list [Li et al. DOI:10.1038/s41598-025-99619-z].