Basic Information

Symbol
SPOP
RNA class
mRNA
Alias
Speckle Type BTB/POZ Protein Speckle-Type POZ Protein BTBD32 TEF2 Roadkill Homolog 1 HIB Homolog 1 NEDMACE NEDMIDF NSDVS1 NSDVS2
Location (GRCh38)
17:49598884-49678201
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001007228.2
Sequence length
2850.0 nt
GC content
0.4491

Transcripts

ID Sequence Length GC content
NM_001007226.1 NCBI
GGGGAGGAGGCCGCGCGGGGUGGGGUCUGGCGGUACGCGCUGGCUGCGU… 3105 nt 0.4589
NM_001007227.1 NCBI
GGGGAGGAGGCCGCGCGGGGUGGGGUCUGGCGGUACGCGCUGGCUGCGU… 2983 nt 0.4539
NM_001007228.2 NCBI
GACGCCCCGGCUGGUGUGUGUCGGUGUGUAUGUGUGUGUGUGAGUGUGC… 2850 nt 0.4491
NM_001007229.1 NCBI
GGGGAGGAGGCCGCGCGGGGUGGGGUCUGGCGGUACGCGCUGGCUGCGU… 2982 nt 0.4517
NM_001007230.1 NCBI
GGGGAGGAGGCCGCGCGGGGUGGGGUCUGGCGGUACGCGCUGGCUGCGU… 3034 nt 0.4519
NM_001370730.1 NCBI
AGACGGUCACCCAGGCUGUAGUGCAGUGGCGUGAUCUCGGCUCACUGUG… 3139 nt 0.4399
NM_001370731.1 NCBI
AGACGGUCACCCAGGCUGUAGUGCAGUGGCGUGAUCUCGGCUCACUGUG… 3088 nt 0.4417
NM_001370732.1 NCBI
CCAAGUAGCUGGGAUUACAGGGUGAAGAGGGAACAGAAAUCUUUGCCCC… 2705 nt 0.4377
NM_003563.3 NCBI
GGGGAGGAGGCCGCGCGGGGUGGGGUCUGGCGGUACGCGCUGGCUGCGU… 3053 nt 0.4589
Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] CIViC Summary for SPOP Gene

Forensic Context

No relevant information is available at the moment.