Basic Information

Symbol
SPP1
RNA class
mRNA
Alias
Secreted Phosphoprotein 1 Lnc-PKD2-2-3 Osteopontin ETA-1 BSPI BNSP OPN Early T-Lymphocyte Activation 1 Urinary Stone Protein Nephropontin Uropontin Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1) Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein Bone Sialoprotein I SPP1/CALPHA1 Fusion Bone Sialoprotein 1 SPP-1
Location (GRCh38)
4:87975667-87983532
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001040058.2
Sequence length
1561.0 nt
GC content
0.4113

Transcripts

ID Sequence Length GC content
NM_000582.3 NCBI
AGCAGCAGGAGGAGGCAGAGCACAGCAUCGUCGGGACCAGACUCGUCUC… 1519 nt 0.4121
NM_001040058.2 NCBI
AGCAGCAGGAGGAGGCAGAGCACAGCAUCGUCGGGACCAGACUCGUCUC… 1561 nt 0.4113
NM_001040060.2 NCBI
AGCAGCAGGAGGAGGCAGAGCACAGCAUCGUCGGGACCAGACUCGUCUC… 1480 nt 0.4061
NM_001251829.2 NCBI
AGCAGCAGGAGGAGGCAGAGCACAGCAUCGUCGGGACCAGACUCGUCUC… 1438 nt 0.4068
NM_001251830.2 NCBI
AGCAGCAGGAGGAGGCAGAGCACAGCAUCGUCGGGACCAGACUCGUCUC… 1750 nt 0.4137
Summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in mice demonstrated that the monocyte/macrophage-associated gene SPP1 was significantly upregulated in myocardial tissues following acute myocardial infarction, as validated by qRT-PCR in an AMI mouse model [Yang et al. DOI:10.2147/JIR.S516092]. A study in human bone demonstrated that the protein OSTP_HUMAN showed clear visual and significant negative trends with increasing postmortem interval (PMI) [Bonicelli et al. DOI:10.7554/eLife.83658].