Basic Information

Symbol
SPRED2
RNA class
mRNA
Alias
Sprouty Related EVH1 Domain Containing 2 Spred-2 Sprouty-Related, EVH1 Domain-Containing Protein 2 FLJ21897 FLJ31917 Sprouty Protein With EVH-1 Domain 2, Related Sequence NS14
Location (GRCh38)
2:65310851-65432637
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_181784.3
Sequence length
4519.0 nt
GC content
0.5094

Transcripts

ID Sequence Length GC content
NM_001128210.2 NCBI
AUCCGGUACAAUGCAGUAUAUUUGUCAAGGAGACUGAAUCAUAUAUGGG… 4070 nt 0.4794
NM_181784.3 NCBI
GCACUCCACCACCUCUGGCCGCUGGGAAGACGUCAUCGCUUCCGCCCUA… 4519 nt 0.5094
Summary

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in humans and mice demonstrated that SPRED2 was upregulated in whole blood cells and peripheral blood mononuclear cells of patients who developed heart failure after acute myocardial infarction [Chen et al. DOI:10.3389/fimmu.2022.878876].