Basic Information

Symbol
SPRR1A
RNA class
mRNA
Alias
Small Proline Rich Protein 1A Cornifin-A Small Proline-Rich Protein IA 19 KDa Pancornulin SPR-IA SPRK Small Proline-Rich Protein 1A
Location (GRCh38)
1:152984081-152985814
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005987.4
Sequence length
648.0 nt
GC content
0.5386

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-174.4 kcal/mol
Thermodynamic ensemble
Free energy: -186.21 kcal/mol
Frequency: 0.0000
Diversity: 129.63
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
............(((.......((...(((((((........((((..........))))..((.(((....))))))))))))...))..(((((((.......(((((((..((((..((((((......))).))).....(((......))).....((((...........(((.((.(.(.((((....)))).).).)))))...........))))(((.((...)))))....((((((..(((((((.((((.....(((((..(((...((.((......)).)))))..)))))....(((((.......(((((((((((..((((((((..((((.((((....)).))))))...)))))......)))..))))....)))))))............(((..((((......))))..))))))))..................((......))((.(((....))).))..............)))))))))))..))))))))))...)))))))..(((.....))).((((.............))))))))))).((((((..(((((.(((((.((.((....)).)).))))))))))..))))))...............))).
Thermodynamic Ensemble Prediction
...........{((........((...(((((((........,,{,..........}}}}..((.(((....))))))))))))...))..(((((((.......(((((((..((((..((((((......)))}|||..,..(((......)))..,..|||,...........(((,((,(,{,(({{....|||||..|,||}}}...........)))}{{(.((,.,|,,,}....{(((({.,({(((((.({{(.....(((((..(((...{(.{,......)),,,)))..))))).,..,,||||......(((((((((((..((((((((..((((.((((....)).))))))...)))))......)))..)))}...,))))))),,{.....,,,.{{{..{{((.....,||}}..))}}))})}|}...,}}.........||}}....))}}}|,.....|||.|...........,...))))))))))),,)})))}))))...)))))))..(((.....))).((((.............))))))))))).{((((((.((({{{(((((.((.((....)).)).)))))))))))))))))}.........,,,...,}}.

Transcripts

ID Sequence Length GC content
NM_001199828.2 NCBI
ACCAAACCCAAGGGACCACACAGCCCAUUCUGCUCCGUAUACCAGCUUU… 662 nt 0.5363
NM_005987.4 NCBI
ACCAAACCCAAGGGACCACACAGCCCAUUCUGCUCCGUAUACCAGAAAA… 648 nt 0.5386
Summary

A structural constituent of skin epidermis. Involved in keratinocyte differentiation and peptide cross-linking. Located in cornified envelope. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the SPRR1A as a stable mRNA marker for saliva identification, demonstrating its predominant expression in oral and esophageal epithelia with no detectable expression in semen and showing tissue-specific expression in stains aged up to 180 days [Zubakov et al. DOI:10.1007/s00414-007-0182-6]. The SPRR1A is recognized as a specific marker for saliva in forensic body fluid identification [Liu et al. DOI:10.1007/s00414-025-03656-2]. The literature review notes that the SPRR1A is a protein marker found in vaginal fluid for body fluid identification [Alex et al. DOI:10.1016/j.scijus.2025.101320].