Basic Information

Symbol
SPRR3
RNA class
mRNA
Alias
Small Proline Rich Protein 3 Small Proline-Rich Protein 3 22 KDa Pancornulin Cornifin Beta Esophagin SPRC
Location (GRCh38)
1:153001747-153003856
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001097589.2
Sequence length
900.0 nt
GC content
0.5022

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-246.5 kcal/mol
Thermodynamic ensemble
Free energy: -261.97 kcal/mol
Frequency: 0.0000
Diversity: 222.49
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((..(((((..((.............(((((((..(((.((((.((...((.((((((((((.(((((....(((.(((((.((((((........((((((.(((.....))).).)))))............((((((....(((.((((.....((((.(((.......((((((............))))))......))).))))......)))).)))..))))))......(((.((((.((((((..(.(((..((((((((.((((((..(.(((..((((((((.((((((..(.((....))))))).))))))..).)))..)))))))).))))))..).)))..)))))))).))))))....)))))))))((((...)))).........((((...))))...))))).....((..((((.((((((.((.........((((.....)))).........)).)))).))))))..)).....)))...)))))))))..)))))).))...))...))))..)))..)))).)))...(((((((((....((((((((((((((....((((((.((.......((((((..(((........))))))))).....)).)))))))))))))).(((..(((.......)))..)))............................((((.......))))))))))....)))))))))....))..)))))..((((((((..(((..(((((...(.(((((((((.....))).)))))).).)))))..))))))))))))))))(((.....(((((...(((..(((.......)))..)))..)))))......))).........
Thermodynamic Ensemble Prediction
..(((({..,,((((.,{....,,}},..,,{{(((((..(((.(({(,((...((.((((((((((.(((((....(((.(((((.((((((........((((({.(((.....})},),)))))..........,.((((((....((({((,,...,{(((,.,.|,,,....((((((.{........,.)))))).....{|||{{.|,....,.))))})||{,}||||}.,,...|||,{{{{||{|{||||,.(({..{{{,{(((.({({((,,|.{{{..|||,{(((.{{{{||..|.|||..|}},)))).)}}))),,}.}}}..))),)))).))))))..}.}))..))),)))).))))))....,,,,}))}}((((...))))...,.....((((...))))..,))))).....((..((((.((((((.((.......,,((((.....)))).,,......)).)))).))))))..)).....)))...)))))))))..}))))).))...))...)))),.)))..))))),),...{((((((((....((((((((((((((....((((((.((.......((((((..(((........))))))))).....)).)))))))))))))).(((..(((.......)))..))).....,,,....,|,.............{{{{.......)))}))))))....))))))))}........,}}}}..((((((((..(((..(((((...(.(((((((((.....)))))))))).).)))))..)))))))))))})))),,{,.,..(((((...(((..(((.,.....)))..)))..))))).,,,,.}}}.........

Transcripts

ID Sequence Length GC content
NM_001097589.2 NCBI
ACCAGAUCCCAGAGGCUGAACACCUCGACCUUCUCUGCACAGCAGGUCC… 900 nt 0.5022
NM_005416.3 NCBI
ACCAGAUCCCAGAGGCUGAACACCUCGACCUUCUCUGCACAGCAGAUGA… 984 nt 0.4959
Summary

Predicted to enable structural molecule activity. Predicted to be involved in keratinocyte differentiation and wound healing. Located in Golgi apparatus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the SPRR3 as a stable mRNA marker for saliva identification, showing predominant expression in oral and esophageal epithelia with no detectable expression in semen and demonstrating tissue-specific expression in stains aged up to 180 days [Zubakov et al. DOI:10.1007/s00414-007-0182-6]. Subsequent research confirmed its stability in saliva stains for up to 6 months under controlled conditions, establishing its utility for post-mortem interval estimation through degradation pattern analysis [Kumar et al. DOI:10.1016/J.Jflm.2025.103044]. A study in humans identified the SPRR3 as a target for LC-MS analysis in novel method development for vaginal fluid identification [Sakurada et al. DOI:10.3390/diagnostics10090693].