Basic Information

Symbol
SPRY1
RNA class
mRNA
Alias
Sprouty RTK Signaling Antagonist 1 HSPRY1 Protein Sprouty Homolog 1 Spry-1 Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) Sprouty Homolog 1, Antagonist Of FGF Signaling
Location (GRCh38)
4:123396754-123403760
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001258038.2
Sequence length
2603.0 nt
GC content
0.4476

Transcripts

ID Sequence Length GC content
NM_001258038.2 NCBI
GUAGCCGGAGUGAGACCGCUCUGCAAACCACUGCGUGCUUUGCAGAGUG… 2603 nt 0.4476
NM_001258039.1 NCBI
GCGCUCCAACUCCGGCGAUGCCGCCUCGCCCUCCCCGCCGCGGUUGAUG… 2370 nt 0.4414
NM_001375410.1 NCBI
GUAGCCGGAGUGAGACCGCUCUGCAAACCACUGCGUGCUUUGCAGAGUG… 3260 nt 0.4988
NM_005841.3 NCBI
AGCUCCACCGUGGUAACUUGCAAUGUGGCCGCCCCUGCGCUGGCUUCUU… 2474 nt 0.4361
NM_199327.3 NCBI
GUAGCCGGAGUGAGACCGCUCUGCAAACCACUGCGUGCUUUGCAGAGUG… 2357 nt 0.4285
Summary

Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in domestic swine demonstrated that the SPRY1 gene, which is targeted by multiple miRNAs, was downregulated at the primary micro-RNA level in heart tissue following induced myocardial infarction [Kaikkonen et al. DOI:10.1161/CIRCGENETICS.117.001702].