Basic Information

Symbol
SQLE
RNA class
mRNA
Alias
Squalene Epoxidase Squalene Monooxygenase SE EC 1.14.14.17 ERG1
Location (GRCh38)
8:124998467-125022287
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003129.4
Sequence length
2962.0 nt
GC content
0.4652

Transcripts

ID Sequence Length GC content
NM_003129.4 NCBI
GAGACGCGUGGAGCCUGGCGGCGAGUGGGGGCGUGCGACGGUUACUCUG… 2962 nt 0.4652
Summary

Enables FAD binding activity and squalene monooxygenase activity. Involved in lipid droplet formation; regulation of cell population proliferation; and sterol biosynthetic process. Located in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in rats demonstrated that the SQLE, a gene involved in cholesterol metabolism, exhibited chronically decreased expression following contusive spinal cord injury [Aimone et al. DOI:10.1016/j.expneurol.2004.05.042].