Basic Information

Symbol
SQSTM1
RNA class
mRNA
Alias
Sequestosome 1 P62 P60 P62B A170 OSIL Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa EBI3-Associated Protein Of 60 KDa Oxidative Stress Induced Like Ubiquitin-Binding Protein P62 Autophagy Receptor P62 Sequestosome-1 EBIAP PDB3 Phosphotyrosine Independent Ligand For The Lck SH2 Domain P62 EBI3-Associated Protein P60 Paget Disease Of Bone 3 FTDALS3 NADGP DMRV ZIP3 ORCA
Location (GRCh38)
5:179806398-179838078
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003900.5
Sequence length
2840.0 nt
GC content
0.5708

Transcripts

ID Sequence Length GC content
NM_001142298.2 NCBI
GGCUUCCGGCCGCCUUCCGCGGCCACCGCCGGGCCCGCUCCCGCCGCCG… 2911 nt 0.5661
NM_001142299.2 NCBI
AAAGGGGCCGCAGCACCGCCGUCGCCGGCGCCGCGAGGGGGUGGGGUGG… 2827 nt 0.5638
NM_003900.5 NCBI
ACGGCCCGUUUUCCGCCAGCUCGCCGCUCGCUAUGGCGUCGCUCACCGU… 2840 nt 0.5708
Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

Forensic Context

A study in rats demonstrated that the SQSTM1 was significantly altered in expression on day 1 and day 2 following a 20% total body surface area burn injury, as part of a comprehensive analysis of 740 significantly altered genes in liver tissue [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].