Basic Information

Symbol
SRC
RNA class
mRNA
Alias
SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase C-Src SRC1 ASV V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog Proto-Oncogene Tyrosine-Protein Kinase Src Proto-Oncogene C-Src EC 2.7.10.2 P60-Src Protooncogene SRC, Rous Sarcoma Tyrosine-Protein Kinase SRC-1 Tyrosine Kinase Pp60c-Src Pp60c-Src EC 2.7.10 THC6
Location (GRCh38)
20:37344673-37406050
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_198291.3
Sequence length
4644.0 nt
GC content
0.5930

Transcripts

ID Sequence Length GC content
NM_005417.5 NCBI
CAUUUCACCAGCCCAGGCUGGCUUCUGCUGUUGACUGGCUGUGGCACCU… 4717 nt 0.5853
NM_198291.3 NCBI
AUUCCGGCCUGGGAGCCGGAGCGGCCAGGCCGCCGUCUGCCCGUCCCGC… 4644 nt 0.5930
Summary

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase . Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.