Basic Information

Symbol
SRD5A2
RNA class
mRNA
Alias
Steroid 5 Alpha-Reductase 2 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) Type II 5-Alpha Reductase 5 Alpha-SR2 SR Type 2 S5AR 2 Steroid 5-Alpha-Reductase 2 EC 1.3.1.22
Location (GRCh38)
2:31522480-31580941
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000348.4
Sequence length
4519.0 nt
GC content
0.4346

Transcripts

ID Sequence Length GC content
NM_000348.4 NCBI
CUGGGAGGGCAGCGGCCACCGGCGAGGAACACGGCGCGAUGCAGGUUCA… 4519 nt 0.4346
Summary

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the SRD5A2 is expressed in specific fibroblast subclusters (FB1, FB4, and part of FB3) within the corpus cavernosum, with SRD5A2+ cells spatially located around the septum pectiniforme [Zhao et al. DOI:10.1038/s41467-022-31950-9].