Forensic Context

A study in humans demonstrated that the SREBF1 mRNA exhibits rhythmic expression with peak levels between 9:00 h and 15:00 h, and its expression pattern was used alongside three other rhythmic mRNAs to construct a k-nearest neighbor regression model for estimating bloodstain deposition time within a 24-hour cycle, achieving a mean absolute error of 3.92 hours [Cheng et al. DOI:10.1016/J.Fsigen.2023.102910]. Separately, a bioinformatics analysis in humans identified the SREBF1 as a predicted transcriptional regulator of key hub proteins in cardiomyopathy, with receiver operating characteristic curve analysis showing an area under the curve of 0.925, indicating strong diagnostic potential [Rahman et al. DOI:10.1038/s41598-024-78011-3]. A study in mice and other models demonstrated that the SREBF1 is a transcription factor involved in lipid metabolism and adipogenesis, where ectopic expression alongside PPARγ can revert activated hepatic stellate cells to a quiescent state [Michalik, L.; Wahli, W. DOI:10.1172/JCI27958]. In a human forensic autopsy pilot study, RNA sequencing analysis of a fatal insulin overdose case identified the SREBF1 as an upregulated downstream effector within the activated insulin signaling pathway [Nakao, Naoki et al. DOI:10.1016/j.legalmed.2025.102772].