Basic Information

Symbol
SREBF2
RNA class
mRNA
Alias
Sterol Regulatory Element Binding Transcription Factor 2 SREBP2 BHLHd2 Sterol Regulatory Element-Binding Protein 2 Class D Basic Helix-Loop-Helix Protein 2 SREBP-2 Sterol Regulatory Element-Binding Transcription Factor 2 BHLHD2
Location (GRCh38)
22:41833099-41907308
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004599.4
Sequence length
5237.0 nt
GC content
0.5805

Transcripts

ID Sequence Length GC content
NM_004599.4 NCBI
CUUUCUGUGCGGCGCCCGGGCGCAACGCAAACAUGGCGGCGGGUGGCAC… 5237 nt 0.5805
Summary

This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Forensic Context

A study in rats demonstrated that the SREBF2 (sterol regulatory element binding transcription factor 2) was identified as a potential RNA marker for methamphetamine reward and addiction through transcriptome profiling of whisker follicles, showing a constant-down regulated expression pattern (0.94 at MASA, 0.55 at WD) and ranking with a betweenness centrality score of 0.0211 [Song et al. DOI:10.1038/s41598-018-29772-1].