Basic Information

Symbol
SRGN
RNA class
mRNA
Alias
Serglycin PRG1 PPG PRG Secretory Granule Proteoglycan Core Protein Hematopoietic Proteoglycan Core Protein Platelet Proteoglycan Core Protein Proteoglycan 1, Secretory Granule Serglycin Proteoglycan P.PG Proteoglycan Protein Core For Mast Cell Secretory Granule Secretory Granule Proteoglycan Core Peptide Hematopoetic Proteoglycan Core Peptide Hematopoetic Proteoglycan Core Protein
Location (GRCh38)
10:69088103-69104811
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002727.4
Sequence length
1217.0 nt
GC content
0.3796

Transcripts

ID Sequence Length GC content
NM_001321053.2 NCBI
AUUCUUGAAGGUUAGAGCUCAGCUUUGAAGUUUCACUUCACGAGCUUGG… 1350 nt 0.3874
NM_001321054.1 NCBI
GAAAUUGUGACGUGUGUUCUGGGCAGGGUUUGAGGUUUUGGAACAUUUU… 1166 nt 0.3654
NM_002727.4 NCBI
ACAUUUCCUAAUCAAGAAGUUGGCGUGCAGCUGGGAGAGCUAGACUAAG… 1217 nt 0.3796
Summary

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

Forensic Context

No relevant information is available at the moment.