Basic Information

Symbol
SRP68
RNA class
mRNA
Alias
Signal Recognition Particle 68 Signal Recognition Particle 68 KDa Protein Signal Recognition Particle Subunit SRP68 Signal Recognition Particle 68kDa Signal Recognition Particle 68kD SCN10
Location (GRCh38)
17:76038775-76072517
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014230.4
Sequence length
2831.0 nt
GC content
0.4906

Transcripts

ID Sequence Length GC content
NM_001260502.2 NCBI
GUCUUGCUCUGCGGCGCAGGGGCAAGAUGGCUGCUGAGAAGCAGGUCCC… 2717 nt 0.4928
NM_001260503.2 NCBI
GACUUUUUCCUUCAUUGCUUUUUAGGAUGUUUGUAAAAUUCCCAGUGGG… 2035 nt 0.4786
NM_014230.4 NCBI
GUCUUGCUCUGCGGCGCAGGGGCAAGAUGGCUGCUGAGAAGCAGGUCCC… 2831 nt 0.4906
Summary

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

Forensic Context

A study in human menstrual blood-derived mesenchymal stem cells (MenSCs) from women with endometriosis identified the SRP68 as a protein overexpressed in the endometriosis group compared to controls [Penariol et al. DOI:10.3390/ijms231911515].