Basic Information

Symbol
SRPK2
RNA class
mRNA
Alias
SRSF Protein Kinase 2 SFRS Protein Kinase 2 SFRSK2 Serine/Arginine-Rich Protein-Specific Kinase 2 Serine/Arginine-Rich Splicing Factor Kinase 2 SR-Protein-Specific Kinase 2 SR Protein Kinase 2 EC 2.7.11.1 Serine/Threonine-Protein Kinase SRPK2 Serine Kinase SRPK2
Location (GRCh38)
7:105110704-105399308
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182692.3
Sequence length
3679.0 nt
GC content
0.4300

Transcripts

ID Sequence Length GC content
NM_182691.3 NCBI
AGGCCUGAUGCCUCUGGAGCUUUUUCCCUUUAUAGCACCAUUGAAUCCC… 3740 nt 0.4163
NM_182692.3 NCBI
AGGCGCGGUUCUCGUCUCCUCCCGGCCGGCGGAGCGAGUGGAGGCUGCA… 3679 nt 0.4300
Showing 11 to 12 of 12 entries
Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the SRPK2 was down-regulated in brain tissue at 8 hours (0.481-fold) and 24 hours (0.493-fold) following whole-body irradiation with 10 Gy γ-rays, where it was categorized as both a cell cycle and a transcription/translation marker in response to ionizing radiation [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418].