Basic Information

Symbol
SRPK3
RNA class
mRNA
Alias
SRSF Protein Kinase 3 MSSK1 STK23 Serine/Threonine-Protein Kinase 23 Muscle-Specific Serine Kinase 1 SR-Protein-Specific Kinase 3 Serine/Threonine Kinase 23 SFRS Protein Kinase 3 EC 2.7.11.1 MSSK-1 Serine Arginine Rich Protein-Specific Kinase 3 Serine/Arginine-Rich Protein-Specific Kinase 3 Serine/Threonine-Protein Kinase SRPK3 XLID114
Location (GRCh38)
X:153781001-153785768
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014370.4
Sequence length
1960.0 nt
GC content
0.6276

Transcripts

ID Sequence Length GC content
NM_001170760.2 NCBI
AGGAGCAGCCGCCCGGGGCACCGGAGCUGCGGGCUGCGUGGCCGGGAUG… 1957 nt 0.6275
NM_001170761.2 NCBI
AGGAGCAGCCGCCCGGGGCACCGGAGCUGCGGGCUGCGUGGCCGGGAUG… 1858 nt 0.6206
NM_014370.4 NCBI
AGGAGCAGCCGCCCGGGGCACCGGAGCUGCGGGCUGCGUGGCCGGGAUG… 1960 nt 0.6276
Summary

This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Forensic Context

A study in mice selectively bred for high or low methamphetamine consumption identified the SRPK3 as a network hub node among ventral midbrain differentially expressed genes overexpressed in the low-drinking line, where it exhibited connectivity differing by at least 0.5 and was a hub in the green coexpression module [Hitzemann et al. DOI:10.3390/brainsci9070155].