Basic Information

Symbol
SRSF4
RNA class
mRNA
Alias
Serine And Arginine Rich Splicing Factor 4 SRP75 Splicing Factor, Arginine/Serine-Rich 4 Serine/Arginine-Rich Splicing Factor 4 SFRS4 Pre-MRNA-Splicing Factor SRP75 SR Splicing Factor 4 SRP001LB
Location (GRCh38)
1:29147743-29181922
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005626.5
Sequence length
2300.0 nt
GC content
0.5143

Transcripts

ID Sequence Length GC content
NM_005626.5 NCBI
GCGUGCUCGCGUACGUCGCCGGGGUUCGGCUGCGUCCGUCCCGCCGCCC… 2300 nt 0.5143
Summary

Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the expression stability of candidate reference genes, including Srsf4, was evaluated in a multiple-trauma model combining long bone fracture and traumatic brain injury [Otto et al. DOI:10.1038/s41598-020-71895-x].