Basic Information

Symbol
SRSF5
RNA class
mRNA
Alias
Serine And Arginine Rich Splicing Factor 5 SRP40 HRS Splicing Factor, Arginine/Serine-Rich 5 Serine/Arginine-Rich Splicing Factor 5 SFRS5 Pre-MRNA-Splicing Factor SRP40 Delayed-Early Protein HRS SR Splicing Factor 5
Location (GRCh38)
14:69726893-69773904
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001320214.2
Sequence length
1496.0 nt
GC content
0.4298

Transcripts

ID Sequence Length GC content
NM_001039465.2 NCBI
GUCAGUUGUGGAGUGGCGUAGACGAGUUAAGUCCUGGUCUGCGUGGAGG… 1621 nt 0.4423
NM_001320214.2 NCBI
GUCAGUUGUGGAGUGGCGUAGACGAGUUAAGUCCUGGUCUGCGUGGAGG… 1496 nt 0.4298
NM_001411040.1 NCBI
GUCAGUUGUGGAGUGGCGUAGACGAGUUAAGUCCUGGUCUGCGUGGAGG… 1263 nt 0.4830
NM_006925.5 NCBI
GUCAGUUGUGGAGUGGCGUAGACGAGUUAAGUCCUGGUCUGCGUGGAGG… 1492 nt 0.4296
Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Forensic Context

A study in mice demonstrated that the SRSF5 mRNA was down-regulated (0.35-fold) in bone marrow cells 6 hours after 6.5 Gy whole-body ionizing radiation [Dai et al. DOI:10.1080/09553000600857389].