Basic Information

Symbol
SRSF7
RNA class
mRNA
Alias
Serine And Arginine Rich Splicing Factor 7 Serine/Arginine-Rich Splicing Factor 7 SFRS7 AAG3 9G8 Splicing Factor, Arginine/Serine-Rich 7, 35kDa SR Splicing Factor 7 Splicing Factor 9G8 ZCCHC20 ZCRB2 HSSG1 RBM37 Splicing Factor, Arginine/Serine-Rich 7 (35kD) Splicing Factor, Arginine/Serine-Rich 7 Aging-Associated Protein 3
Location (GRCh38)
2:38743599-38751494
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001031684.3
Sequence length
2356.0 nt
GC content
0.3998

Transcripts

ID Sequence Length GC content
NM_001031684.3 NCBI
GUAGUGCCGCCGGGACUCUUGGCGGGUGAAGGUGUGUGUCAGCUUUUGC… 2356 nt 0.3998
NM_001195446.2 NCBI
GUAGUGCCGCCGGGACUCUUGGCGGGUGAAGGUGUGUGUCAGCUUUUGC… 2320 nt 0.3991
NM_001363802.1 NCBI
AGUCUCUUCAGUUCCUUCCGCGUCGUUUCUUGGCUGUUUCCGCCCAGCU… 2480 nt 0.4097
Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

Forensic Context

A study in humans demonstrated that the SRSF7 (SRSF7) expression was significantly decreased in the peripheral blood mononuclear cells of sepsis patients compared to healthy controls, as validated by RT-qPCR [Shi et al. DOI:10.3389/fimmu.2025.1640425].