Basic Information

Symbol
SRY
RNA class
mRNA
Alias
Sex Determining Region Y TDF Sex-Determining Region Y Protein Testis-Determining Factor Essential Protein For Sex Determination In Human Males Testis-Determining Factor On Y Sex-Determining Region On Y SRXX1 SRXY1 TDY
Location (GRCh38)
Y:2786855-2787682
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003140.3
Sequence length
828.0 nt
GC content
0.4662

Transcripts

ID Sequence Length GC content
NM_003140.3 NCBI
AGAAGUGAGUUUUGGAUAGUAAAAUAAGUUUCGAACUCUGGCACCUUUC… 828 nt 0.4662
Summary

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the SRY is a highly expressed circular RNA in testes [Memczak et al. DOI:10.1038/nature11928].