Basic Information

Symbol
SSH2
RNA class
mRNA
Alias
Slingshot Protein Phosphatase 2 KIAA1725 Protein Phosphatase Slingshot Homolog 2 SSH-Like Protein 2 SSH-2L Slingshot Homolog 2 (Drosophila) EC 3.1.3.16 EC 3.1.3.48 HSSH-2L SSH-2 SSH2L
Location (GRCh38)
17:29625938-29930276
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001282129.2
Sequence length
9484.0 nt
GC content
0.4610

Transcripts

ID Sequence Length GC content
NM_001282129.2 NCBI
AUUGUGCCCCGCAGCUGCGGAACCGCCCGCCCGCCGCCCGUUCGGAGCG… 9484 nt 0.4610
NM_001282130.2 NCBI
AUUGUGCCCCGCAGCUGCGGAACCGCCCGCCCGCCGCCCGUUCGGAGCG… 1082 nt 0.4908
NM_001282131.2 NCBI
AGUCCGGACUCUACCGCCGAGCCCUGGGGCUUCGGCGGCUGCCUCCGCG… 1030 nt 0.4816
NM_033389.3 NCBI
GACAAGAAUGCCCUGCCCGGAACAACCCAGCAGCGCCUAGAUGGCUUUG… 9224 nt 0.4559
Summary

This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SSH2 in oligodendrocytes, where it is associated with the regulation of the actin cytoskeleton pathway [Oladapo et al. DOI:10.3390/Ijms26020649]. A study in mice demonstrated that methamphetamine treatment induced transcriptomic changes in ileal tissue, with RNA sequencing identifying 326 differentially expressed genes and bioinformatics analysis revealing enrichment in pathways including regulation of the actin cytoskeleton [Sun et al. DOI:10.21037/Atm-20-7741].