Basic Information

Symbol
SSR1
RNA class
mRNA
Alias
Signal Sequence Receptor Subunit 1 TRAPA Translocon-Associated Protein Subunit Alpha Signal Sequence Receptor Subunit Alpha Signal Sequence Receptor, Alpha SSR-Alpha Translocon-Associated Protein Alpha Subunit Translocon-Associated Protein Alpha SSR Alpha Subunit TRAP Alpha TRAP-Alpha
Location (GRCh38)
6:7268306-7347446
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003144.5
Sequence length
9661.0 nt
GC content
0.4055

Transcripts

ID Sequence Length GC content
NM_001292008.2 NCBI
GGAUGAAGAGUAACGCCAUUACCGCCGGAGCCGCCGAGAGCCUUAGCCG… 9457 nt 0.4053
NM_003144.5 NCBI
GGAUGAAGAGUAACGCCAUUACCGCCGGAGCCGCCGAGAGCCUUAGCCG… 9661 nt 0.4055
Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Forensic Context

A study in humans demonstrated that the SSR1 exhibited a Gini impurity score of 0, being present in all pure vaginal fluid samples and in some mixtures containing vaginal fluid, with minimal occurrence in mixtures without vaginal fluid, supporting its role as a discriminatory protein for body fluid classification [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].