Basic Information

Symbol
SST
RNA class
mRNA
Alias
Somatostatin SMST SST1 Growth Hormone Release-Inhibiting Factor Prepro-Somatostatin Somatostatin-14 Somatostatin-28
Location (GRCh38)
3:187668912-187670394
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001048.4
Sequence length
607.0 nt
GC content
0.5470

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-188.8 kcal/mol
Thermodynamic ensemble
Free energy: -198.73 kcal/mol
Frequency: 0.0000
Diversity: 158.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((((.(((((((..(.(((....))).).)))).......))).))))))))((.((((........((((((..(((((((.((.((((....(((((((((((((.(((((.(((((((((..((((.(((((..((....))..))))).))))..))))))).....((((........)))).((((((((((.....((((((((....)))).))))..))))))))))((((((.....))))))....((.(((((((........)))))))))......)).))))).((((...........))))..)).).))))))........((.(((((..((((....))))...))))).))))))..)))).)).)))))..))..)))))).((((((..((((..(((.(((((((..(((..(((((((.....))))).))...)))....(((((....))))).......................................)))))))))).))))..))))))((((...))))....(((....)))...........)))).))...........
Thermodynamic Ensemble Prediction
.......((((({((.((({((({{({{((,,..|||,,.}}}},|,|,}|})}.}}}}}})}{{,{{{{,,...,,,((((((,,((,{{{(,((,((((....{{{{{{{{{{|{|.(((((.({(((((((..((((.(((((..((....))..))))).)))},.))))))).,.,,{|||...,,,.,||}}.((((((((((.....((((((((....)))).))))..))))))))))((((((.....)))))).,,,||.(((((((........)))))))}}......|},||||,,({,(.....,.,}.,)))),.)),).)))))),,....,.{{.(((((.,((((....))))...))))).)}))))..)))).}},))))}..))..)))))).{(((((..{{((,,{{{{({(((({..,,,..,,(((({.....}}))).}}...,}}....(((((....))))).....,.................................})))))))}}.))))..)))))},,||...},},....{{{....,},...........}))).,,...........

Transcripts

ID Sequence Length GC content
NM_001048.4 NCBI
ACAAGCCGCUUUAGGAGCGAGGUUCGGAGCCAUCGCUGCUGCCUGCUGA… 607 nt 0.5470
Summary

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Forensic Context

A study in cynomolgus macaques demonstrated that chronic methamphetamine administration decreased hippocampal expression of the SST mRNA, a neuropeptide that protects against glutamate-induced excitotoxicity, as measured by RT-qPCR [Choi et al. DOI:10.1016/j.taap.2018.05.031].