Basic Information

Symbol
SSTR2
RNA class
mRNA
Alias
Somatostatin Receptor 2 Somatostatin Receptor Type 2 SRIF-1 SST2 SS2R SS-2-R SS2-R
Location (GRCh38)
17:73165010-73176633
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001050.3
Sequence length
7685.0 nt
GC content
0.4569

Transcripts

ID Sequence Length GC content
NM_001050.3 NCBI
AGUCCCAGCGGCGCAGCCACCCAUGCGCGCGCGCUCGCAAGACCACCAG… 7685 nt 0.4569
Summary

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Forensic Context

Soluble suppression of tumorigenicity-2 (sST2) is a reported biomarker related to heart failure triggered by acute myocardial infarction [Chen et al. DOI:10.1186/s12920-021-00890-6], though its reliability remains controversial [Chen et al. DOI:10.3389/fimmu.2022.878876]. The SSTR2 is recognized as a myocardial stress marker that can identify heart failure patients at risk of sudden cardiac death [Lou et al. DOI:10.1016/j.jflm.2022.102332].