Basic Information

Symbol
ST6GAL1
RNA class
mRNA
Alias
ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 CDw75 SIAT1 CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 1 ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 Alpha 2,6-ST 1 ST6Gal I ST6GalI CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase) Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialytransferase) B-Cell Antigen CD75 Sialyltransferase 1 EC 2.4.99.1 EC 2.4.3.1 ST6N
Location (GRCh38)
3:186930325-187078932
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_173216.2
Sequence length
4604.0 nt
GC content
0.5002

Transcripts

ID Sequence Length GC content
NM_001353916.2 NCBI
GUCUCUUAUUUUUUGCCUUUGCAGAUGAGUUUUGAUCAUCCUGAGAAAA… 4177 nt 0.4812
NM_003032.3 NCBI
GAACUUUCUGAUAGCUUAAUAGGAGGAGGUUCCUGUAGGGCGGCACAAC… 4303 nt 0.4820
NM_173216.2 NCBI
GCUCUUCUUCCUUCCUUCUCCAGUCCCUUCCACUGUGCGUCUUCUGUCC… 4604 nt 0.5002
NM_173217.2 NCBI
GCUCUUCUUCCUUCCUUCUCCAGUCCCUUCCACUGUGCGUCUUCUGUCC… 3947 nt 0.4989
Summary

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Forensic Context

A study in humans demonstrated that the ST6GAL1 mRNA was significantly upregulated in salivary extracellular vesicles from patients with mild traumatic brain injury (mTBI) compared to controls, and its expression also showed a significant difference between acute emergency department patients and those from an outpatient concussion clinic [Cheng et al. DOI:10.1002/jcp.28139]. A separate study in mice found that the ST6GAL1 gene was upregulated in white blood cells at day 1 post-injury as part of a common cell-to-cell signaling response following both burn injury and trauma-hemorrhage [Lederer et al. DOI:10.1152/physiolgenomics.00086.2007].